The latest and greatest on prevention and detection...not just Alzheimer's Disease, sharing info on all types of dementia and cognitive prevention including Parkinson's as it is closely related. May just incorporate this one into one of the other Alzheimer's pages I have, lots of cross-over with trials, grants, etc.
3/9/20
Here’s Why Losing Sleep
For Only One Night May Cause Alzheimer’s Disease.
Losing just one night
of sleep fuels brain proteins linked to the development of Alzheimer’s
disease, a new research warns.
The study, published in the journal Neurology, found that when young,
healthy men were deprived of just one night of sleep, they had higher
levels of tau, a biomarker for Alzheimer’s disease, in their blood than
when they had a full, uninterrupted night of rest...
https://www.newsgram.com/losing-sleep-one-night-cause-alzheimers-disease
Here’s Why Losing Sleep
For Only One Night May Cause Alzheimer’s Disease. Read more at:
https://www.newsgram.com/losing-sleep-one-night-cause-alzheimers-disease
3/5/20
Subtle Cognitive Decline Predicts Alzheimer’s Pathology
Low-cost, noninvasive cognitive testing may help identify people at risk of progressing to the first stage of Alzheimer’s disease, according to a study published online in Biological Psychiatry.
“Stage 1 of
the National Institute on Aging–Alzheimer’s Association’s proposed
Alzheimer’s disease continuum is defined as amyloid-β (Aβ) positive but cognitively normal. Identifying at-risk individuals before Aβ reaches
pathological levels could have great benefits for early intervention,”
researchers wrote.https://www.psychcongress.com/article/subtle-cognitive-decline-predicts-alzheimers-pathology
3/3/20
Researchers Identify New Alzheimer’s Biomarker in PSEN1 Gene
Researchers have identified a gene called Presenilin1, or PSEN1, as a potential new biomarker for Alzheimer’s disease. In mice and human samples, the researchers found in a new study that DNA activity changes in the PSEN1 gene are associated with Alzheimer’s...
https://www.beingpatient.com/researchers-identify-new-alzheimers-biomarker-psen1/
The study:
CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain
https://www.tandfonline.com/doi/full/10.1080/15592294.2020.1722917
New Blood Test Could Make Alzheimer’s Diagnosis Easier Than Ever
A simple blood test may soon be able to diagnose patients with two common forms of dementia – Alzheimer’s disease and frontotemporal dementia (FTD) – and tell the two apart.
Researchers at UC San Francisco analyzed the blood test in more than 300 patients and say they hope to see such a test available in doctor’s offices within five years...
https://www.ucsf.edu/news/2020/03/416761/new-blood-test-could-make-alzheimers-diagnosis-easier-ever
3/2/20
Potential genetic test for earlier Alzheimer's diagnosis
A new study published in the journal Epigenetics in February 2020 reports that changes in the methylation status of the Presenilin 1 (PSEN1) gene could help diagnose Alzheimer's disease (AD) earlier. This study shows for the first time that methylation of this gene is a common feature in AD.
https://www.news-medical.net/news/20200301/Potential-genetic-test-for-earlier-Alzheimers-diagnosis.aspx
3/1/20
Alzheimer’s Risk: Test Your Eyes
There are several types of dementia as per the American Academy of Ophthalmology. Alzheimer’s Disease (AD) is the most common of all. In fact, it was noted by the academy that AD comprises about 60 to 80% of dementia cases in recent times. However, there is a huge challenge in the field when it comes to diagnosing the early stages of the disease.
https://thebossmagazine.com/alzheimers-eye-test/
2/26/20
My thoughts: There are a lot of good suggestions and the author gives a good overall picture of where we currently stand in regards to treating and preventing dementia and related brain issues. However, the only time dance is mentioned in the article is as a subtitle for a paragraph on aerobic exercise...which still doesn't mention dance. I suppose it is implied --- but saying that a few simple dance steps can help is a stretch...BUT, the article is still well worth a read.
Dancing Can Help Prevent Dementia
A few simple steps (dance steps that is) can help you reduce the risk of Alzheimer’s.https://thriveglobal.com/stories/dancing-can-help-prevent-dementia/
2/21/20
Microdosed LSD: Finally A Breakthrough For Alzheimer’s Disease?
After decades of effort and untold millions invested in the search for an effective treatment for Alzheimer’s, the disease remains unchecked and rampant. Most recently, the New York Times reported that researchers declared defeat after the failure of yet another experimental drug designed to fight the formation of the disease’s signature amyloid plaque in the brain...
https://www.forbes.com/sites/abbierosner/2020/02/21/microdosed-lsd-may-finally-be-the-breakthrough-for-alzheimers-disease/#6e32728753a8
Researchers discover Mediterranean diet ingredient may extend life
Researchers at the University of Minnesota Medical School discover a potential new way in which diet influences aging-related diseases.
Doug Mashek, Ph.D., a professor in the Departments of Medicine and Biochemistry, Molecular Biology and Biophysics, leads a team of researchers who discovered that olive oil in the Mediterranean diet may hold the key to improving lifespan and mitigating aging-related diseases...https://medicalxpress.com/news/2020-02-mediterranean-diet-ingredient-life.html
Ketone-Rich Diets May Reduce Alzheimer’s Disease Risk
The latest findings implicate that the consumption of ketones may be a way of protecting interneurons and delaying the progression of Alzheimer’s disease. By preserving mitochondrial function, SIRT3 protects interneurons against amyloid beta-induced dysfunction and degeneration in mice with Alzheimer’s disease. According to Dr. Chang and her team, “the neuronal network dysfunction that occurs in Alzheimer’s disease can be partially reversed by physiological, dietary, and pharmacological interventions to increase SIRT3 expression and enhance the functionality of GABAergic interneurons.”...
https://www.worldhealth.net/news/ketone-rich-diets-may-reduce-alzheimers-disease-risk/
SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model
SIGNIFICANCE STATEMENT GABAergic neurons provide the main inhibitory control of neuronal activity in the brain. By preserving mitochondrial function, SIRT3 protects parvalbumin and calretinin interneurons against Aβ-associated dysfunction and degeneration in AppPs1 Alzheimer's disease mice, thus restraining neuronal network hyperactivity. The neuronal network dysfunction that occurs in Alzheimer's disease can be partially reversed by physiological, dietary, and pharmacological interventions to increase SIRT3 expression and enhance the functionality of GABAergic interneurons...
https://www.jneurosci.org/content/40/3/694
2/18/20
Cleveland Clinic launches 'wellness checkup” for the brain that could predict Alzheimer’s diagnosis
A simple test during your annual physical could cut the number of people who develop Alzheimer’s Disease by half, according to officials from the Cleveland Clinic.
https://www.news5cleveland.com/lifestyle/cleveland-clinic-launches-wellness-checkup-for-the-brain-that-could-predict-alzheimers-diagnosis
Would you wear a device that helps detect Alzheimer's? (Video News Story)
https://www.oanow.com/video/news/would-you-wear-a-device-that-helps-detect-alzheimer-s/video_648c82e8-8147-5d68-8d19-9e942fe359b8.html
Wearable to spot Alzheimer's being developed
An ambitious project to develop a wearable device to detect early signs of Alzheimer's disease has been launched.
The Early Detection of Neurodegenerative diseases (Edon) is being spearheaded by charity Alzheimer's Research UK.It will initially analyse data from continuing studies into the disease, using artificial intelligence.
And this data will be used to design a prototype device within three years.
https://www.bbc.com/news/technology-51474115
2/16/20
Subtle differences in cognitive performance predict progression to Alzheimer's pathology
In the progression of AD, Aβ levels build in the brain, but the process leading to abnormally high levels is typically long. It is often years or decades before consequential symptoms of severe cognitive impairment appear. A new framework from the National Institute on Aging and Alzheimer's Association defines the first stage of AD to be individuals with abnormal levels of Aβ who are still cognitively normal...
https://www.news-medical.net/news/20200216/Subtle-differences-in-cognitive-performance-predict-progression-to-Alzheimers-pathology.aspx
2/14/20
Molecular Switch Reverses Chronic Inflammation & Aging
A molecular switch has been identified by scientists at the University of California that controls the immune machinery which is responsible for chronic inflammation within the body; findings published in the journal Cell Metabolism may lead to new ways to halt and/or reverse age related conditions such as cancer, diabetes, Alzheimer’s and Parkinson’s disease...
https://www.worldhealth.net/news/molecular-switch-reverses-chronic-inflammation-aging/
Can bilingualism protect the brain even with early stages of dementia?
Researchers find bilingualism provides the brain with greater cognitive reserve, delaying onset of symptoms
TORONTO, February 13, 2020 - A study by York University psychology researchers provides new evidence that bilingualism can delay symptoms of dementia...
https://www.eurekalert.org/pub_releases/2020-02/yu-cbp021320.php
2/12/20
Identified a brain circuit that could indicate the risk of developing Alzheimer's
Researchers from IDIBELL and CIBERSAM have discovered how alterations in the connectivity of two regions of the brain represents a potential biomarker for Alzheimer's vulnerability
Late-onset Alzheimer's disease (LOAD), the one that appears after age 65, is the most common form of this neurodegenerative disease and accounts for more than 90% of cases. The first brain changes associated with the disease may appear years before the first symptoms, but the lack of clear risk markers complicates the application of the appropriate prevention strategies for those that are more vulnerable...
https://www.eurekalert.org/pub_releases/2020-02/ibri-iab021220.php
2/11/20
Cassava Phase IIa study of PTI-125 in Alzheimer’s prevention shows promise
With recent news on Roche (ROG: SIX) and Eli Lilly (NYSE: LLY) failing to meet primary endpoint in their Alzheimer's trial, added to dozens of other failures, Cassava Sciences looks to focus on a drug that has a different target approach. PTI-125 is a proprietary small molecule that restores the normal shape and function of FLNA in the brain. This action improves the function of certain receptors in the brain, slows neurodegeneration and exerts powerful anti-neuroinflammatory effects...
https://www.thepharmaletter.com/article/cassava-phase-iia-study-of-pti-125-in-alzheimer-s-prevention-shows-promise
Potential role for regular aerobic exercise in Alzheimer’s disease prevention
In a pilot study, researchers investigated the potential of regular aerobic exercise in Alzheimer’s disease prevention.
Alzheimer’s disease is the most common type of dementia, a progressive brain condition that impairs memory, thought processes, and behavior. Dementia usually affects older people, although it is not a normal part of aging...
https://medicalnewsbulletin.com/potential-role-for-regular-aerobic-exercise-in-alzheimers-disease-prevention/
Brain Food: Influencing Alzheimer Disease Risk With Dietary Intake
Recently published study data from the community-based Memory and Aging Project (MAP) has suggested that a higher dietary intake of flavonols may be associated with a lower risk of developing Alzheimer disease dementia.
https://www.neurologytimes.com/alzheimer-disease/brain-food-influencing-alzheimer-disease-risk-dietary-intake
2/8/20
Can Coffee Reduce Your Risk of Alzheimer’s Disease?
Story at-a-glance
- A report revealed coffee could potentially reduce the risk of developing neurodegenerative conditions or relieve some symptoms
- The results support past studies that found coffee protects the neurological system, reduces cognitive decline and improves insulin sensitivity
- Rates of Alzheimer's Disease are rising. It is also called Type 3 diabetes, as the effect of insulin dysregulation in the brain may induce changes seen in Alzheimer's Disease
- More possible benefits from coffee include reduced risks of dying early and of contracting certain cancers and Type 2 diabetes; it also may boost athletic performance
- Coffee crops are heavily sprayed with pesticides, so seek out organic selections; consider grinding it at home and drinking it without sugar
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