Sunday, March 15, 2020

Great article on Creatine...

She sometimes talks (and writes) way over my head as I'm an artist, not a scientist or doctor, but I always understand enough without having to go get a medical degree... So, here's one of Dr. Rhonda Patrick's breakdowns of the latest and greatest on creatine.

https://www.foundmyfitness.com/topics/creatine
Creatine is a naturally occurring compound that plays major roles in the storage and release of cellular energy. It also participates in a wide range of biological processes involved in improving pregnancy outcomes, maintaining bone mineral density and muscle mass in the elderly, improving neurological function, and aiding the immune system to fight cancer. Creatine is perhaps best known for its widespread use as a dietary supplement to enhance physical performance...

Wednesday, March 4, 2020

Cancellations due to Coronavirus and the Impact

Everyone is hearing about people stocking up, hoarding, canceling vacations and business trips. The media is constantly ratcheting up our heartbeats, adding to fears...and who knows yet whether this will just be another Y2K type scare or a real pandemic?

We're watching the stock market on a downhill trajectory. Many of us have heard how this could impact drugs and supplements, electronics, other items we use regularly. The big guys are more than likely going to weather this one. They may take some hits but they will recover.

It's the small guys who are going to be hurt the worst. They may not have viable back-ups for their suppliers. They are often on a shoe-string budget. They don't have the advertising dollars. They may not have a huge Internet presence.

Have you thought about the small businesses that depend on trade shows? They are the lifeblood for untold numbers of companies across the globe. Many companies don't have storefronts, they sell mostly at trade shows. There is an entire workforce that makes their living working these shows in various capacities. Not to mention the hits the promoters and convention centers are going to take as they are forced to cancel or see dwindling visitors. We are going to be buying more and more on-line.

I wish my results looked this good!
Personally, I've decided to revive my garden. I am going to need some new gardening tools. I figure it's going to get harder to get fresh foods whether this is a real threat or not --- fear is going to choke the food industry, too. I have always preferred food I grew myself, may as well use this to spur my butt to get back to it! I traveled a lot in the past and it was hard to keep plants going. I've cut back on my shows...and now the Coronavirus is cutting back on the shows I can do...so, no excuses. Time to grow some maters! If it will ever stop raining...

I wonder how this is going to impact concerts? The theater? Restaurants? Hotels? Small grocery stores? Small retail businesses? Realtors? --- the more we fear contagion the more we're going to stay home. I'm not letting it stop me but dang...go to any store and they are our of the useless face masks...the bleach, alcohol, peroxide shelves are emptying...cleaning supplies and germ killers are disappearing... Oh, and as I shopped yesterday at Wal-Mart the stockers were talking about their emptying shelves, how they were having to substitute products when doing the shopping for those coming for pick-up...canned goods are a hit currently!

Here's just the first page of a quick search I did about trade shows canceling:
  1. How trade shows have been hit hard by coronavirus - BBC News
    https://www.bbc.co.uk/news/business-51439403
    The show, which is due to take place 5-15 March, is one of the most important events in the motor industry calendar, as the platform for some of the world's most high-profile new car launches.
  2. CP+ 2020 Trade Show Canceled Due to Coronavirus Fears
    https://www.pcmag.com/news/cp-plus-2020-trade-show...
    CP+ 2020 Trade Show Canceled Due to Coronavirus Fears. The Camera and Photo Imaging Show was set to take place in Yokohama, Japan from Feb. 27 and attracted nearly 70K visitors last year.
  3. MWC 2020 canceled over coronavirus health concerns - The Verge
    https://www.theverge.com/2020/2/12/21127754/mwc...
    Feb 12, 2020 · After coronavirus threatened to throw MWC into chaos, the GSM Association (GSMA), which organizes the show, has now canceled it. It comes after more than a week of exhibitors and companies pulling...
  4. Trade Shows: Additional trade shows postponed due to corona
    https://www.sportswear-international.com/news/stories/Trade-Shows-Further-trade-shows...
    The effects of the coronavirus are spreading further. Now also the Denimandjeans Tokyo show (scheduled from March 4-5, 2020) has been postponed. Sandeep Agarwal, the organizer of Denimandjeans, says: “ We have been studying the virus situation for a few days and we felt that we could not take a chance on the health of our exhibitors, visitors and our team as well.
  5. CP+ 2020 Cancelled due to Coronavirus - Newsshooter
    https://www.newsshooter.com/2020/02/14/cp-2020-cancelled-due-to-coronavirus
    CP+ 2020, one of the largest photography trade shows in the world has been canceled due to fears over the Coronavirus. The Diamond Princess cruise ship which is currently docked in Yokohama where CP+ was to be held has so far had 174 passengers diagnosed with the COVID-19 virus.
  6. Coronavirus forces cancellation, delay of trade shows ...
    https://www.businesstimes.com.sg/government-economy/coronavirus-forces-cancellation...
    OVER two dozen large trade fairs and industry conferences in Singapore, China and elsewhere have been postponed due to travel curbs and concerns about the spread of a coronavirus, potentially disrupting billions of dollars worth of deals. Here is a snapshot of some of the major events that have been scrapped, postponed or scaled back.
  7. Portland trade show canceled over coronavirus concerns ...
    https://www.kptv.com/news/portland-trade-show-canceled-over-coronavirus-concerns/...
    Organizers decided on Wednesday to cancel the show due to concerns surrounding the coronavirus and people traveling from China. The organizers say the coronavirus is already starting to impact...
  8. Coronavirus: Major tech event canceled as Bay Area ...
    https://www.sfchronicle.com/business/article/Coronavirus-Major-tech-event-canceled-as...
    Feb 12, 2020 · Coronavirus: Major tech event canceled as Bay Area companies stay away A major annual conference and trade show in Barcelona, Spain, that draws some 100,000 participants from Silicon Valley and...
  9. What Event Organizers Need to Know About Coronavirus and ...
    https://www.tsnn.com/news/what-event-organizers-need-know-about-coronavirus-and...
    They’re reaching out to her as a result of groups wanting to cancel events without penalties, due to the coronavirus. What Event Organizers Need to Know About Coronavirus and Canceling Contracts | TSNN Trade Show News
  10. Trade Show Executive :: Coronavirus Postpones Trade Shows ...
    https://tradeshowexecutive.com/archive/industry...
    BEIJING — A number of trade shows and B2B events in Shanghai, Macau and Guangzhou are being postponed due to the outbreak of novel coronavirus in China. Many postponements and cancelations are expected follow as officials around the world grapple with containing the rising number of people infected with the virus.

Monday, March 2, 2020

Epsom Salt..love soaking in a tub with it!

For as long as I can remember (adult remembering :-), I have loved soaking in a tub with added Epsom Salt. I used it quite a bit when I was running and doing a lot of weight work to ease my sore muscles. I still use it to relax, to help get rid of bruises, for ingrown toenails (once), and to help my sleep.

I love that it doesn't dry out my skin. It leaves it feeling nice and soft after a bath.

Many doctors, functional and traditional, suggest it for their patients to help with a number of health issues. I've compiled a list below of things that I came across while researching.

I always learn so much when I start researching a topic! I will definitely be taking more nice, long, hot baths at night before bed in the future. 

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Side note: Wondering why I'm focusing on Epsom Salts? A "traditional" doc ala one knows medicine but doesn't know nutrition or anything "natural", mocked, to a patient, a previous doctor's recommendation to take an Epsom Salt bath. First, what kind of doctor laughs at another doctor who trained the same way he did, plus extended their training to include more nutrition, more "whole-body" treatments? Second, why do that as a human being? I like the guy but that one really burned me... He missed the part where the doctor was pushing that same patient to have a scan to find out what was going on with her stomach, bowels, the hardness she felt when she did her exam... I'm betting he didn't check her stomach. Hmph. Not all doctors are alike. Some follow up, send emails to find out how their patients are doing, do extra research to find ways to help and think outside the box a bit within medical reason. OK, stopping my rant :-). But I do love my doctor...she is the first doctor I have ever had who listens, who asks questions, who goes above and beyond.

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Like many other "home" remedies there isn't a lot of research. But what there is does support it as a reasonable, useful addition to our home health arsenal. Unless something has money-making potential dollars don't flow for studies. Epsom Salt is cheap. It is never going to make those who fund studies, primarily drug companies*, any money.

Most of us know we can drink the stuff and poop like crazy. It tastes horrible, but it works. Just don't overdo it. Bleh. Why would you when magnesium works just as well? Oh, wait, Epsom salt is a mineral compound of magnesium...and sulfate. The full, correct, name is magnesium sulfate heptahydrate.  Still, magnesium, especially in drinks like Calm, works just as well.


Ever wonder where the word "Epsom" came from? Epsom is a spring in Surrey, England where it originated from and was distilled from the water. In today's world, it is derived from mining.

From Salt Works, https://seasalt.com/epsom-salt-uses-and-benefits
"Studies have shown that magnesium and sulfate are both readily absorbed through the skin**, making Epsom salt baths an easy and ideal way to enjoy the associated health benefits. Magnesium plays a number of roles in the body including regulating the activity of over 325 enzymes, reducing inflammation, helping muscle and nerve function, and helping to prevent artery hardening. Sulfates help improve the absorption of nutrients, flush toxins, and help ease migraine headaches.

Here is a list of things Epsom Salts, known to be anti-inflammatory, may help with --- some possibly better if you take it rather than soak in it, but then why not just take magnesium?:
  • Arthritis pain and swelling
  • Bruises and sprains
  • Making insulin more productive
  • Fibromyalgia
  • Ingrown toenails
  • Insomnia
  • Psoriasis and other skin issues
  • Sore muscles
  • Athlete's foot
  • Soreness from diarrhea during chemotherapy
  • Flushing toxins (there is a lot of debate on this one in regards to detoxing via soaking in a tub)
  • Sunburn pain and redness
  • Decreasing the oil in your hair (mix some with hair conditioner)
  • Blood pressure 
  • Gout pain
  • Exfoliating your skin
  • Constipation (FDA approved as a laxative)
  • Tired, swollen feet
  • Reducing inflammation to help get out splinters (reducing inflammation is a good idea whether you have a splinter or not :-)) 
  • Relieve pain from bug bites and bee stings
  • There is one study that indicates soaking can help someone lose weight...I'm a bit skeptical on this one as I would weigh 10 lbs by now as many baths as I've had over the years!
  • Fertilizing your yard
  • Bug spray (for your yard, getting rid of pests on your plants) 
  • Combined with dish soap it's good for scrubbing counters and tiles
This site has a long list of things that Epsom Salt can do, too. Check it out: https://preparednessmama.com/25-uses-for-epsom-salts/

Dr. Rosemary Waring, a British biochemist, Univerity of Birmingham, is a strong proponent of using Epsom Salts to help with autism and has a number of studies. Here are a few links that mention Waring as a source, the first two deal more with autism. I would suggest doing a search on Waring and autism if that is an area you are interested in pursuing.

Too much is not a good thing so be sure to read the package labels. Watch out if you are also taking a magnesium supplement. It can make some medications harder to absorb so check with your doctor if you're taking antibiotics or other medications.

Additions if you're using it in a bath:
  • Olive oil
  • Baking soda
  • Peroxide
  • Essential oils like lavender, frankincense, orange
  • Apple cider vinegar
  • Coconut oil
  • Fresh rosemary (good for your memory also)
  • Bentonite clay
  • Here's a recipe for an oatmeal, rose soak that sounds great: https://www.diynatural.com/homemade-oatmeal-bath-recipe/

* I plan to do a blog on who funds studies at some point. I read that statement over and over in my research travels but haven't verified it myself.
** There is debate on how much if any is absorbed through the skin. There ARE studies showing it is absorbed...but there are skeptics, too. Well, actually, I found two articles that were skeptical and about a bazillion that promoted and said the salt was great. Figured in the interest of being fair that I should at least mention that some doubted.

https://www.webmd.com/a-to-z-guides/epsom-salt-bath#1
https://www.bobvila.com/articles/epsom-salts-in-the-garden/
https://draxe.com/nutrition/epsom-salt/
https://www.epsomsaltcouncil.org/
https://www.medicalnewstoday.com/articles/321627
https://seasalt.com/epsom-salt-uses-and-benefits

Another one I found fascinating re: Alzheimer's Disease, Dementia


I usually post articles on the pages (links above), and will add this one...but I found it so interesting I decided to give it special stand-alone billing on my blog :-). I am constantly amazed at what they are learning about our brains and how they work.

Can PET Match Up Areas of Protein Deposit With Alzheimer’s Symptoms?
Even though, overall, Alzheimer’s disease robs all people it afflicts of mind and memory, it progresses differently in different people. Its specific symptoms, their sequence, and how fast they worsen can vary quite a bit from one person to another. This used to be a tough nut to crack for researchers, but now, by combining data from multiple PET tracers in longitudinal study cohorts, they are beginning to decipher which regional pathologies provoke particular disease manifestations. The Human Amyloid Imaging conference, held January 15–17 in Miami, showcased the latest findings tying tangles, or plaques, to particular behavioral and cognitive impairments. Intriguingly, links between pathology and subtle symptoms emerged even in people who were still cognitively healthy. The data suggest that multitracer, and also multimodal, brain imaging may eventually allow researchers to predict how disease will progress in a given person...
https://www.alzforum.org/news/conference-coverage/can-pet-match-areas-protein-deposit-alzheimers-symptoms

Sunday, March 1, 2020

Short Sleep Gene?

How I wish I slept...
I came across this article while doing some research on sleep studies. It really struck me as I have a "short sleep" gene...and I pretty much miss the mark when it comes to hitting over 6 hours of sleep. I am going to now have to set up alerts so I can watch this one.

I don't get tired. I am not sleepy during the daytime. I start getting tired around 9 or 9:30 p.m. and am generally out by 10 - 10:30.

Do you have trouble getting over 6 hours of sleep? Are you tracking your sleep and finding that you don't get sufficient REM and/or deep sleep? Read the article and let me know what you think!

Short Sleeper: Short Sleep Syndrome
If you usually get less than seven hours of sleep, you are probably a short sleeper. Many people are short sleepers due to lifestyle choices. For example, juggling work, recreation, and family responsibilities may not leave enough hours in the day to get the recommended amount of sleep each night.
But it’s not just the number of hours we spend asleep. It’s also the quality of your sleep that matters. Some people do not spend enough time in deep sleep. So, even if they get seven hours of sleep, it may not be good quality and restorative sleep they need.
If you are a short sleeper or do not get enough deep sleep, you might feel tired the next day and lack energy, which can affect your day to day activities.
https://www.sleepassociation.org/sleep-disorders/short-sleeper/


Some of my previous blogs on sleep:

https://ramblingjan.blogspot.com/2020/02/going-for-sleep-study-tips-for-getting.html

https://ramblingjan.blogspot.com/2020/02/suffered-through-sleep-study.html

https://ramblingjan.blogspot.com/2020/02/melatoninits-good-for-more-than-sleep.html

https://ramblingjan.blogspot.com/2020/02/to-sleep-or-not-to-sleepthat-is-question.html

Alzheimer's drugs...more failures and a few promising trials starting...

I've posted about the failure of mainstream Alzheimer's treatments before...I think the focus on amyloid plaques is mistaken. Yes, there seems to be some good reason to address the tangles and build up in the brain at some point. However, if you're not fixing the cause of the plaque attack then it's going to happen again and be potentially worse, possibly a rebound effect?

Thus far the ONLY treatments that are working for the long-term are those that test for health issues, change diets, lifestyles, add targeted high-quality supplements to stop the root causes. Take a look at my page with recommended reading (link above) and you'll see a number of books focused on functional healing and reversal of Alzheimer's Disease and other related brain issues.

Here's a few of the latest on drugs in testing and some getting ready to start:

EXCELLENT article...

As another Alzheimer's treatment fails, experts are divided on where to next
Before I have a chance to ask dementia researcher Amy Brodtmann about the failure of yet another Alzheimer's treatment, she wants to make one thing clear.
"Whenever these drugs fail, you can't underestimate how devastating it is."
After three decades of research and billions of dollars of investment, news that another Alzheimer's drug treatment has failed means an effective treatment for the common degenerative disease is still out of reach...
https://www.abc.net.au/news/health/2020-02-26/alzheimers-drug-failure-raises-questions-about-research/11996258

My comments: At first, I thought, wow, great...although I much prefer to figure out the root causes, address those and keep it from happening...but for those looking for a magic pill the first part of the article seemed positive, as does the end...but the one sentence I pulled below shows the problems with treatments that don't address WHY...
A new treatment for Alzheimer’s
Their research has shown that, in small doses, the metal lithium is capable of reducing Alzheimer’s symptoms and could prevent the emergence of Alzheimer’s in people with a genetic predisposition to the disease. ...
...Yet the treatment cannot remedy the symptoms of Alzheimer’s once severe cognitive decline has set in; it is only effective in low doses over sustained periods before dementia symptoms appear...
http://www.mcgilltribune.com/sci-tech/a-new-treatment-for-alzheimers-250220/

ProMIS Neurosciences Initiates Natural History Study of Blood-Based Biomarkers in Alzheimer’s Disease
 
TORONTO and CAMBRIDGE, Mass., Feb. 26, 2020 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), with Toronto Memory Program, Canada’s largest and most experienced memory clinic and site for drug treatment trials in Alzheimer’s disease (AD) has initiated a pilot longitudinal study to assess the level of blood-based biomarkers in early AD with the support of Parexel, one of the world’s leading global clinical research organizations (CROs). ProMIS will leverage Parexel’s significant data management and central nervous system (CNS) expertise for the study, which it will use as the historical control arm for its anticipated Phase 1 study of PMN310, a novel antibody that selectively targets the toxic oligomeric species of amyloid beta, a root cause of AD. The dataset will help ProMIS detect a treatment signal as early as Phase 1, potentially allowing for rapid proof-of-concept at a fraction of the expense associated with traditional clinical trials. The dataset will be made available as a communal resource for Alzheimer’s researchers...
https://www.globenewswire.com/news-release/2020/02/26/1990787/0/en/ProMIS-Neurosciences-Initiates-Natural-History-Study-of-Blood-Based-Biomarkers-in-Alzheimer-s-Disease.html

UPDATE 1-Roche drug fails in early-onset Alzheimer's disease study
* Study fails in inherited form of Alzheimer’s
* Roche says 2 additional trials to continue
* 100s of Alzheimer’s drug trials have flopped (Adds details throughout, comment from Roche)
https://www.reuters.com/article/roche-alzheimers/update-1-roche-drug-fails-in-early-onset-alzheimers-disease-study-idUSL8N2AA0QG

Drugs fail to slow decline in inherited Alzheimer's disease
Two experimental drugs have failed to prevent or slow mental decline in a study of people who are virtually destined to develop Alzheimer's disease at a relatively young age because of rare gene flaws
https://abcnews.go.com/Health/wireStory/drugs-fail-slow-decline-inherited-alzheimers-disease-68881708
...The study tested solanezumab by Eli Lilly & Co., and gantenerumab by Swiss drugmaker Roche and its U.S. subsidiary, Genentech. Both drugs gave disappointing results in some earlier studies, but the doses in this one ranged up to four to five times higher and researchers had hoped that would prove more effective...

Israeli startup hopes to battle Alzheimer’s with enzyme-busting drug
After testing in lab, ProteKt Therapeutics says compound that inhibits the PKR enzyme can lead to cognitive improvements and slow the disease’s progress; road ahead is long
...Nisemblat is aware that the way ahead is long and precarious and because there is no clear, single cause of Alzheimer’s disease there is also “no single target” to aim at in trying to beat the illness.
“The traditional treatments are not beneficial,” he said. The industry has been seeking new ways to slow down the illness’s progression and halt patents’ deterioration...
https://www.timesofisrael.com/israeli-startup-hopes-to-battle-alzheimers-with-enzyme-busting-drug/ 


Adding Michael Pollan to my reading, listening list...

I have Google Alerts set up on a number of topics, some fun, most serious and related to health (mine or someone in my family). I remember seeing Michael Pollan's name in some of the articles I've read but have not taken the time to listen or find out more. He has been around for quite some time.

Based on some quick reading this morning, Pollan speaks common sense. I love his 7 Rules for Eating. I agree with so much that was attributed to him in the article.

We are obsessed with health in the United States. Yet we have some of the worst eating habits and the worst rates of diseases. It seems everyone is on a diet. I prefer not to think of what I do as a diet --- that is a brain thing as to me a "diet" is negative in my mind, it is something temporary with a specific goal of losing weight for the majority. Sometimes it's a change in reaction to a health scare (heart attack, etc.).

I also think everyone has to find their own way, find a way of eating 

I eat a certain way, I tweak it as I learn more, as I pay attention to my body...but what I'm trying to do is follow Pollan's #1 rule --- I don't eat anything that my grandmother (in my case, my great-grandmother) wouldn't recognize as food. As part of that, I basically try to eat like most did before manufacturers started messing up our food by processing it, spraying our foods with tons of chemicals and pesticides, modifying our foods so they wouldn't die when sprayed with pesticides, filling our cattle with hormones and antibiotics, feeding fish, chickens, and cattle with "foods" they were not intended to eat...I could go on.

We wonder why we are so ill? Why younger people are in the midst of a diabetic epidemic? Why ADD is happening with more and more frequency? Why Alzheimer's Disease and dementias are rising...and to younger and younger ages? Why our population is so obese? It's more than one thing, it's not just food. But food plays a huge part in it!

OK, stepping down from that soapbox! 

I like his 2nd "rule" --- don't eat anything with more than 5 ingredients or ingredients you can't pronounce. And his 3rd --- stay out of the middle of the grocery store, shop the perimeter... and definitely his 4th --- don't eat anything that won't eventually rot!

On the 4th I do bend it a bit. Only because in a tiny, tiny way I am a mini-prepper. I want to have enough food to eat if we lose electricity for a few weeks (which happened to us a few years back during a winter snowstorm). I like frozen foods much, much better than canned or freeze-dried, but if you don't have a freezer ya gotta have somethin' to eat.

The rest of his rules are good also. 5 - don't eat so much, leave the table a little hungry, 6 - eat around the table with family, not the TV and 7 - don't buy food where you buy gas (or I gather if you read the rest, at fast food joints).

Of course, I paraphrased his rules. I would add a few others --- eat organic whenever possible (but especially the Dirty Dozen) and go Non-GMO to avoid all the extra pesticides if you can't find organic.

He is correct when he notes that our food "rules" have changed over the years. One day something is bad, the next it is good. Villains change to heroes overnight. We find that studies promoting certain lifestyles were done by the food industries that would benefit. We find that studies done that changed our way of eating were flawed. New science decides that salt isn't all bad, that cholesterol isn't the bad-guy they thought it was, that it's good to eat fats...and so on.

I'm going to check a few of his books out of the library. I'll let you know what I think. I may just go see if he is on YouTube first. I'll add some links below if I find anything interesting or new.

Ha --- just took a look at the videos and it seems that in addition to talking diet and food Pollan talks a lot about psychedelics. (Here's a first-pass search result: https://www.bing.com/videos/search?q=michael+pollan&qpvt=Michael+Pollan&FORM=VDRE)

https://www.webmd.com/food-recipes/news/20090323/7-rules-for-eating#1

https://en.wikipedia.org/wiki/Michael_Pollan

Disclaimer

I am not a doctor or a medical professional. If you choose to do some of the things I blog about please do your research, talk to your doctor or someone who knows more than I before implementing things.