Alzheimer's drugs...more failures and a few promising trials starting...

I've posted about the failure of mainstream Alzheimer's treatments before...I think the focus on amyloid plaques is mistaken. Yes, there seems to be some good reason to address the tangles and build up in the brain at some point. However, if you're not fixing the cause of the plaque attack then it's going to happen again and be potentially worse, possibly a rebound effect?

Thus far the ONLY treatments that are working for the long-term are those that test for health issues, change diets, lifestyles, add targeted high-quality supplements to stop the root causes. Take a look at my page with recommended reading (link above) and you'll see a number of books focused on functional healing and reversal of Alzheimer's Disease and other related brain issues.

Here's a few of the latest on drugs in testing and some getting ready to start:

EXCELLENT article...
As another Alzheimer's treatment fails, experts are divided on where to next
Before I have a chance to ask dementia researcher Amy Brodtmann about the failure of yet another Alzheimer's treatment, she wants to make one thing clear.
"Whenever these drugs fail, you can't underestimate how devastating it is."
After three decades of research and billions of dollars of investment, news that another Alzheimer's drug treatment has failed means an effective treatment for the common degenerative disease is still out of reach...
https://www.abc.net.au/news/health/2020-02-26/alzheimers-drug-failure-raises-questions-about-research/11996258

My comments: At first, I thought, wow, great...although I much prefer to figure out the root causes, address those and keep it from happening...but for those looking for a magic pill the first part of the article seemed positive, as does the end...but the one sentence I pulled below shows the problems with treatments that don't address WHY...
A new treatment for Alzheimer’s
Their research has shown that, in small doses, the metal lithium is capable of reducing Alzheimer’s symptoms and could prevent the emergence of Alzheimer’s in people with a genetic predisposition to the disease. ...
...Yet the treatment cannot remedy the symptoms of Alzheimer’s once severe cognitive decline has set in; it is only effective in low doses over sustained periods before dementia symptoms appear...
http://www.mcgilltribune.com/sci-tech/a-new-treatment-for-alzheimers-250220/

ProMIS Neurosciences Initiates Natural History Study of Blood-Based Biomarkers in Alzheimer’s Disease 
TORONTO and CAMBRIDGE, Mass., Feb. 26, 2020 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), with Toronto Memory Program, Canada’s largest and most experienced memory clinic and site for drug treatment trials in Alzheimer’s disease (AD) has initiated a pilot longitudinal study to assess the level of blood-based biomarkers in early AD with the support of Parexel, one of the world’s leading global clinical research organizations (CROs). ProMIS will leverage Parexel’s significant data management and central nervous system (CNS) expertise for the study, which it will use as the historical control arm for its anticipated Phase 1 study of PMN310, a novel antibody that selectively targets the toxic oligomeric species of amyloid beta, a root cause of AD. The dataset will help ProMIS detect a treatment signal as early as Phase 1, potentially allowing for rapid proof-of-concept at a fraction of the expense associated with traditional clinical trials. The dataset will be made available as a communal resource for Alzheimer’s researchers...
https://www.globenewswire.com/news-release/2020/02/26/1990787/0/en/ProMIS-Neurosciences-Initiates-Natural-History-Study-of-Blood-Based-Biomarkers-in-Alzheimer-s-Disease.html

UPDATE 1-Roche drug fails in early-onset Alzheimer's disease study
* Study fails in inherited form of Alzheimer’s
* Roche says 2 additional trials to continue
* 100s of Alzheimer’s drug trials have flopped (Adds details throughout, comment from Roche)
https://www.reuters.com/article/roche-alzheimers/update-1-roche-drug-fails-in-early-onset-alzheimers-disease-study-idUSL8N2AA0QG

Drugs fail to slow decline in inherited Alzheimer's disease
Two experimental drugs have failed to prevent or slow mental decline in a study of people who are virtually destined to develop Alzheimer's disease at a relatively young age because of rare gene flaws
https://abcnews.go.com/Health/wireStory/drugs-fail-slow-decline-inherited-alzheimers-disease-68881708
...The study tested solanezumab by Eli Lilly & Co., and gantenerumab by Swiss drugmaker Roche and its U.S. subsidiary, Genentech. Both drugs gave disappointing results in some earlier studies, but the doses in this one ranged up to four to five times higher and researchers had hoped that would prove more effective...

Israeli startup hopes to battle Alzheimer’s with enzyme-busting drug
After testing in lab, ProteKt Therapeutics says compound that inhibits the PKR enzyme can lead to cognitive improvements and slow the disease’s progress; road ahead is long
...Nisemblat is aware that the way ahead is long and precarious and because there is no clear, single cause of Alzheimer’s disease there is also “no single target” to aim at in trying to beat the illness.
“The traditional treatments are not beneficial,” he said. The industry has been seeking new ways to slow down the illness’s progression and halt patents’ deterioration...
https://www.timesofisrael.com/israeli-startup-hopes-to-battle-alzheimers-with-enzyme-busting-drug/ 

Updated 3/1/20 - What is working when it comes to fighting Alzheimer's Disease and other dementias?

Pretty much the only things currently having any kind of an impact long-term on the fight against Alzheimer's Disease (AD) and other forms of dementia all come from the functional side of the medical world.

That's not to say that when caught early the traditional treatments don't always fail. Sometimes, when combined with increased physical exercise, dietary changes and maybe some supplements, early intervention works and continues to work.

Sadly, most people don't talk to their doctors about failing memory until they are past the point of current traditional, mainstream medical treatments working to keep AD at bay. I have personal experience with that silence. Those close to this individual kept everyone in the dark, although to be honest we kind of noticed some signs, just didn't pick up on them as we don't see them except in short doses for holidays. The Bredesen Protocol (see other posts, plus some of my pages linked below the header) could have worked for her but they are no longer following. Long story on that one. Sad, makes me so sad, wakes me up at night thinking about what they are facing.

Anywaze...onto brighter thoughts. Oh, wait, no...the next part deals with the current status of treatments for dementias. Not good news.

Quotes from a variety of articles on the current status of "traditional" treatments (click the quote to read the entire article):

• Previous Alzheimer’s medications have targeted specific toxins that are abundantly present in diseased brains, such as the aforementioned beta amyloid. However, these drugs all failed once going into clinical trials, perhaps because they were only targeting one part of the problem.
• As drug trials fail to find an effective treatment for the most common form of dementia, could it be time to go back to the drawing board?
• Current drugs only temporarily ease symptoms and do not alter the course of the disease.
• Because there are no effective disease-modifying treatments currently available for Alzheimer’s, drugs and other approaches — such as nutritional supplements, or nutraceuticals — designed to stop or slow disease progression have become a focus of ongoing research
• On the treatment front, we still do not know what causes Alzheimer’s disease, and we do not have a cure. The drugs that have been approved slow the progression of symptoms for a period of time, but then the disease takes over again. Someone with Alzheimer’s will die of it or with it.

Great article highlighting the general things we can do to help PREVENT dementia:

https://bewell.stanford.edu/boosting-brain-health/ 

I could have posted a thousand similar quotes. Almost every article has statements of hope about future treatments...but it's almost like they're tossing a tiny bone at the readers or maybe trying to give themselves hope. If you read my blogs, the comments I post on the pages (links above), you know I think they are barking up the wrong tree by focusing on amyloid plaques.

Now for some positive news!

However, we DO have current treatments that are working and have been working. They don't involve drugs and are multi-pronged so there's no money for grants, aside from some small ones for small groups. Also, most doctors have a tendency to look down their noses at what falls under the "functional medicine" heading. Even if their patients ignore their traditional advice and drugs and opt to change their diets, lose weight, exercise, take supplements --- and improve, get better.

I'm a prime example. I had high cholesterol. I balked at taking drugs. My doctor "allowed" me 2 months, which she "graciously" extended to three for me to try and decrease it with exercise and diet. I'll admit, I didn't do much research at the time, upped my exercise routine...and failed. She scared me sufficiently into starting to take the meds. She told me it was hereditary and I just had the gene, was stuck.

A bit later I made some serious changes to my diet. I went gluten-free (before it was a "thing"), took sugar out of my diet and then eventually moved to a plant-based diet. I was vegetarian initially. My cholesterol numbers dropped, I got off the meds...and got off my acid reflux medicine (which another doc said I'd be on for the rest of my life or risk esophageal cancer...they do like to scare one!).

If you're interested in HOPE as opposed to depressing news, a feeling of doom because you have a family history of dementia or Parkinson's, have been diagnosed with MCI (mild cognitive impairment), have found you have one or two APOE4 genes or have a family member dealing with Alzheimer's Disease take a look at the APOE4.info forum --- over 3,500 people who are focused on keeping dementia at bay. There are great success stories. There are many who are discovering the site and taking control of their health daily. You can also find some excellent Facebook groups.

NOTE: Many or most of the following docs see a role for traditional drugs and treatment, they just know that it's a much bigger picture. I agree. I think there is a place for drugs and applaud our great physicians who do a great job. I just think we have a personal responsibility to do our own research, do more than just pop a pill...

Pick up or check out one or all of the following books:
Dr. Dale Bredesen - An End to Alzheimer's
David Perlmutter - Grain Brain
Steven Gundry - The Plant Paradox
Amy Myers - The Thyroid Connection
Terry Wahls - The Wahls Protocol

Or check into Zack Bush, Mark Hyman, Stephen Phinney, Jeff Volek, Valter Longo, Jason Fung, Dave Asprey, Ivor Cummings, Sachi Panda, Rhonda Patrick, Peter Attia. (No particular order of preference and you'll like some, not like others!).

Explaining Functional Medicine...

This guest column says everything I might have said if I'd tried to write about the topic...  The only thing I might quibble over is the title of the article as it's really not a totally new kind of medicine!

A new kind of medicine

The first time I heard the term Functional Medicine (FM) was soon after my mom was diagnosed with Alzheimer’s Disease.

After her diagnosis, she was prescribed medication and we were told the disease would continue to progress until her death. Since then, I have often wondered how different it might have been if years ago we would have had more detailed information about her health. Maybe FM could have made a difference.

http://www.northstarmonthly.com/opinion/a-new-kind-of-medicine/article_231dbc16-5803-11ea-8539-5bfc9aec428f.html