Alzheimer's drugs...more failures and a few promising trials starting...

I've posted about the failure of mainstream Alzheimer's treatments before...I think the focus on amyloid plaques is mistaken. Yes, there seems to be some good reason to address the tangles and build up in the brain at some point. However, if you're not fixing the cause of the plaque attack then it's going to happen again and be potentially worse, possibly a rebound effect?

Thus far the ONLY treatments that are working for the long-term are those that test for health issues, change diets, lifestyles, add targeted high-quality supplements to stop the root causes. Take a look at my page with recommended reading (link above) and you'll see a number of books focused on functional healing and reversal of Alzheimer's Disease and other related brain issues.

Here's a few of the latest on drugs in testing and some getting ready to start:

EXCELLENT article...
As another Alzheimer's treatment fails, experts are divided on where to next
Before I have a chance to ask dementia researcher Amy Brodtmann about the failure of yet another Alzheimer's treatment, she wants to make one thing clear.
"Whenever these drugs fail, you can't underestimate how devastating it is."
After three decades of research and billions of dollars of investment, news that another Alzheimer's drug treatment has failed means an effective treatment for the common degenerative disease is still out of reach...
https://www.abc.net.au/news/health/2020-02-26/alzheimers-drug-failure-raises-questions-about-research/11996258

My comments: At first, I thought, wow, great...although I much prefer to figure out the root causes, address those and keep it from happening...but for those looking for a magic pill the first part of the article seemed positive, as does the end...but the one sentence I pulled below shows the problems with treatments that don't address WHY...
A new treatment for Alzheimer’s
Their research has shown that, in small doses, the metal lithium is capable of reducing Alzheimer’s symptoms and could prevent the emergence of Alzheimer’s in people with a genetic predisposition to the disease. ...
...Yet the treatment cannot remedy the symptoms of Alzheimer’s once severe cognitive decline has set in; it is only effective in low doses over sustained periods before dementia symptoms appear...
http://www.mcgilltribune.com/sci-tech/a-new-treatment-for-alzheimers-250220/

ProMIS Neurosciences Initiates Natural History Study of Blood-Based Biomarkers in Alzheimer’s Disease 
TORONTO and CAMBRIDGE, Mass., Feb. 26, 2020 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), with Toronto Memory Program, Canada’s largest and most experienced memory clinic and site for drug treatment trials in Alzheimer’s disease (AD) has initiated a pilot longitudinal study to assess the level of blood-based biomarkers in early AD with the support of Parexel, one of the world’s leading global clinical research organizations (CROs). ProMIS will leverage Parexel’s significant data management and central nervous system (CNS) expertise for the study, which it will use as the historical control arm for its anticipated Phase 1 study of PMN310, a novel antibody that selectively targets the toxic oligomeric species of amyloid beta, a root cause of AD. The dataset will help ProMIS detect a treatment signal as early as Phase 1, potentially allowing for rapid proof-of-concept at a fraction of the expense associated with traditional clinical trials. The dataset will be made available as a communal resource for Alzheimer’s researchers...
https://www.globenewswire.com/news-release/2020/02/26/1990787/0/en/ProMIS-Neurosciences-Initiates-Natural-History-Study-of-Blood-Based-Biomarkers-in-Alzheimer-s-Disease.html

UPDATE 1-Roche drug fails in early-onset Alzheimer's disease study
* Study fails in inherited form of Alzheimer’s
* Roche says 2 additional trials to continue
* 100s of Alzheimer’s drug trials have flopped (Adds details throughout, comment from Roche)
https://www.reuters.com/article/roche-alzheimers/update-1-roche-drug-fails-in-early-onset-alzheimers-disease-study-idUSL8N2AA0QG

Drugs fail to slow decline in inherited Alzheimer's disease
Two experimental drugs have failed to prevent or slow mental decline in a study of people who are virtually destined to develop Alzheimer's disease at a relatively young age because of rare gene flaws
https://abcnews.go.com/Health/wireStory/drugs-fail-slow-decline-inherited-alzheimers-disease-68881708
...The study tested solanezumab by Eli Lilly & Co., and gantenerumab by Swiss drugmaker Roche and its U.S. subsidiary, Genentech. Both drugs gave disappointing results in some earlier studies, but the doses in this one ranged up to four to five times higher and researchers had hoped that would prove more effective...

Israeli startup hopes to battle Alzheimer’s with enzyme-busting drug
After testing in lab, ProteKt Therapeutics says compound that inhibits the PKR enzyme can lead to cognitive improvements and slow the disease’s progress; road ahead is long
...Nisemblat is aware that the way ahead is long and precarious and because there is no clear, single cause of Alzheimer’s disease there is also “no single target” to aim at in trying to beat the illness.
“The traditional treatments are not beneficial,” he said. The industry has been seeking new ways to slow down the illness’s progression and halt patents’ deterioration...
https://www.timesofisrael.com/israeli-startup-hopes-to-battle-alzheimers-with-enzyme-busting-drug/