Dementia, Parkinson's Disease and our genes...

Two articles. The first I'm posting is much better. Given that I am APOE 3/4 plus have quite a few Parkinson's genes and all kinds of other contributing nasties like short-sleep, etc. I'm primed for a potentially ugly future genetically. However, I am not gonna let those nasties be my future.

One thing I've learned over the past 8 or 9 months of bombarding my brain with all the latest and greatest research, news, podcasts, theories while trying to help my mom is that prevention is possible. The scary thing is that the nasty genes can kick in 20 years or more before you start seeing "symptoms". Often by the time you start experiencing cognitive issues you're in a battle that main-stream science currently says you will lose. There is no cure. Currently. There is great promise for changing that though, just probably not in time to help my mother. Catching it early and/or prevention is critical.

Side note: My uncle has Parkinson's and my mother, grandmother and great-grandmother all have/had some form of dementia. My other aunt has a plethora of health issues, not sure what all of them are as there's not much communication. Not aware of any Parkinson's or dementia on the paternal side of the family, tons of cancer though. And yes, I have all kinds of cancer-related bad genes...

Also, have a ton of SNPs that say I'm primed for Type 2 Diabetes. My mom was diagnosed as pre-diabetic, and told her cholesterol was too high a few years back (not sure exactly when) and they wanted to put her on meds. She changed her diet...lowered her cholesterol...blood tests currently show good on the diabetes front but she is a true sugar-holic & carb-holic (as am I)...however, she went way too far and lost way too much weight, didn't understand eating healthy vs starvation/extremely small portions! Been trying to increase her weight since last June, some success but it's a battle :-).

Anywaze, here are the two articles on Parkinson's, APOE, etc.:

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Gene ID’d as potential therapeutic target for dementia in Parkinson’s
Targeting gene linked to Alzheimer’s may reduce dementia risk in Parkinson’s
Dementia is one of the most debilitating consequences of Parkinson’s disease, a progressive neurological condition characterized by tremors, stiffness, slow movement and impaired balance. Eighty percent of people with Parkinson’s develop dementia within 20 years of the diagnosis, and patients who carry a particular variant of the gene APOE are at especially high risk.

In new research, scientists at Washington University School of Medicine in St. Louis have found a clue to the link between Parkinson’s, APOE and dementia.
https://medicine.wustl.edu/news/gene-idd-as-potential-therapeutic-target-for-dementia-in-parkinsons/

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Lab: Discovery could help stave off anguish of dementia in people battling Parkinson’s

PARKINSON’S disease can be especially cruel. Its slow but sure onset inflicts tremors, slows down movement and impairs balance. And perhaps the most bitter blow of all is that 80 percent of people newly diagnosed will go on to develop dementia within 20 years.

But there is hope for the future, after experts made a breakthrough that could lead to treatments capable of slowing down or stopping this mental decline.

https://www.metro.news/bbc-science-focus-discovery-could-help-stave-off-anguish-of-dementia-in-people-battling-parkinsons/1899963/
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Info at end of first article with study info I think:
Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, Kotzbauer PT, Holtzman DM. APOE Genotype Regulates Pathology and Disease Progression in Synucleinopathy. Science Translational Medicine. Feb. 5, 2020. DOI: 10.1126/scitranslmed.aay3069

Fibromyalgia and Food "Fix"

Years back, when I worked a desk job, I was diagnosed with Fibromyalgia.

I had been running regularly, working out, taking aerobic classes, and was very active (but not overly so). Slowly I got to the point where getting out of bed in the morning was painful. I hurt. I was miserable. Sleep was sporadic and I was slugging through the day.

Luckily, being in a management position which gave me fantastic health benefits, I was able to work with my doctor to try and figure out the cause. We did every test imaginable over a long period of time. Finally I ended up with a rheumatoid specialist who came up with Fibromyalgia.

She gave me a whole slew of prescriptions and toldl me to get on the treadmill and walk for ten minutes a day. I laughed, thinking of the races I used to run & thought she was really underestimating my abilities. I couldn't walk for five minutes.

I filled the prescriptions and took them for a few days. I really, really 1) hated the idea of taking all those pills and 2) hated the side-affects. I stopped and went back to being miserable.

However, I didn't give up. I started a search for another answer. I did NOT like the idea of being weak, spiraling into medicine dependence, or being labeled.

I ultimately went to see a nutritionist. Not your typical hospital nutritionist (here's your food pyramid, eat like it says). I went to a private doctor who believed in using food, vitamins, minerals and all that's natural to combat illnesses.

She put me on what she called a shock diet. Nothing white in my diet at all for two weeks. If it was processed with anything white I couldn't eat it. It truly was a shock. I went through withdrawals I suppose. For about three days I walked from refrigerator to pantry to almost banging into walls as I detoxed from all the junk I had been eating (I thought I was a healthy-eater!). By the time the 2 weeks were over I was comfortable with eating whole foods and rather liked the diet.

Long story, but after the shock diet, dumping all the vitamins I thought I needed and narrowing them down to a few select choices, changing my diet, etc. I have never had any of the symptoms of Fibromyalgia... It wasn't an overnight process but it was a fairly quick turnaround. (Note: when I go back to bad eating habits, don't allow myself to get sufficient sleep, I can tell when my body is heading back in the yikes direction. I adjust and get back on track.)

That was my very first real experience with looking at diet and nutrition as a "cure" rather than going with the drugs most doctors automatically prescribe. Since then I've looked for doctors who say diet, exercise, lifestyle before pulling out the prescription pad. They are hard to find.

When my cholesterol started going up my doctor (at the time) told me I just had bad genes, luck of the draw. She "allowed" me two months to try and decrease it before starting me on Lipitor. It went up. I was half-ass about working on it at the time, bought into "gene" thing.

Later I did some research, read how I could lower it naturally with diet and proper exercise. I ditched the Lipitor. My cholesterol is well below the top range and has stayed there for years. My doctor still insists on testing it more often than usual to monitor :-)

I could tell more tales...I have politely argued with many doctors, done it my way and been successful in every instance. Good research and culling through all the hype of the current fads is crucial.

I'm not saying that diet can cure everything, but we really should give it a shot first. Even if it's not "the" cure eating healthy sure will help with fighting whatever you are facing.

I now have an OK doctor. She's not "into" the same things I am but when I walk in and tell her I'm doing this or that she says OK, try it, go for it, we'll do blood tests and see how it works. She has even given me some natural alternatives when I asked. She's still a prescription pad grabber first type, but she's agreeable to trying other things.

I am getting ready to tell her I've gone totally plant based. That's going to be an interesting conversation!